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SUMOylation of DNA replication proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-4615885

PubChem

R-HSA-4615885

Description

The sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-strand breaks and inappropriate recombination (reviewed in Watts 2006, Watts 2007, Dieckman et al. 2012, Gazy and Kupiec 2012). SUMOylation of Aurora-A, Aurora-B, and Borealin is necessary for proper chromosome segregation. SUMOylation of topoisomerases is observed in response to damage caused by inhibitors of topoisomerases.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 32 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8CG34	Nuclear envelope pore membrane protein POM 121C	POM121C	view
O15504	Nucleoporin NUP42	CG1 NUP42 NUPL2	view
O75694	Nuclear pore complex protein Nup155	KIAA0791 NUP155	view
P11387	DNA topoisomerase 1	TOP1	view
P11388	DNA topoisomerase 2-alpha	TOP2 TOP2A	view
P12004	DNA sliding clamp PCNA	PCNA	view
P12270	Nucleoprotein TPR	TPR	view
P35658	Nuclear pore complex protein Nup214	CAIN CAN KIAA0023 NUP214	view
P37198	Nuclear pore glycoprotein p62	NUP62	view
P46060	Ran GTPase-activating protein 1	KIAA1835 RANGAP1 SD	view

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