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Degradation of AXIN

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-4641257

PubChem

R-HSA-4641257

Description

AXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, however (Lee et al, 2003; Tan et al, 2012). Cellular levels of AXIN are regulated in part through ubiquitin-mediated turnover. E3 ligases SMURF2 and RNF146 have both been shown to play a role in promoting the degradation of AXIN by the 26S proteasome (Kim and Jho, 2010; Callow et al, 2011; Zhang et al, 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 26 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O95271	Poly [ADP-ribose] polymerase tankyrase-1	PARP5A PARPL TIN1 TINF1 TNKS TNKS1	view
P17980	26S proteasome regulatory subunit 6A	PSMC3 TBP1	view
P20618	Proteasome subunit beta type-1	PSC5 PSMB1	view
P25786	Proteasome subunit alpha type-1	HC2 NU PROS30 PSC2 PSMA1	view
P25788	Proteasome subunit alpha type-3	HC8 PSC8 PSMA3	view
P25789	Proteasome subunit alpha type-4	HC9 PSC9 PSMA4	view

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