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SUMOylation of immune response proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-4755510

PubChem

R-HSA-4755510

Description

NF-kappaB transcription factors are sequestered in the cytosol due to their association with IkappaB. During activation of NF-kappaB, IKK phosphorylates IkappaB, releasing NF-kappaB for importation into the nucleus. NF-kappaB transcription factors, the NFKBIA component of IkappaB, and subunits of the IKK complex can be SUMOylated (reviewed in Kracklauer and Schmidt 2003, Liu et al. 2013). SUMOylations of IkappaB, NFKBIA, and RELA inhibit NF-kappaB signaling; SUMOylation of NFKB2 is required for proteolytic processing.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P19525	Interferon-induced, double-stranded RNA-activated protein kinase	EIF2AK2 PKR PRKR	view
P63165	Small ubiquitin-related modifier 1	OK/SW-cl.43 SMT3C SMT3H3 SUMO1 UBL1	view
Q00653	Nuclear factor NF-kappa-B p100 subunit	LYT10 NFKB2	view
Q04206	Transcription factor p65	NFKB3 RELA	view

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