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Signaling by RNF43 mutants

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5340588

PubChem

R-HSA-5340588

Description

RNF43 and related protein ZNRF3 are E3 ubiquitin ligases that negatively regulate WNT signaling by downregulating FZD receptors at the cell surface (Mukai et al, 2010; Hao et al, 2012). Frameshift loss-of-function mutations in RNF43 that enhance WNT signaling have been identified in pancreatic and colorectal cancers; the proliferation of these cells is dependent on the presence of secreted WNT, as their growth is abrogated by treatment of cells with the Porcupine inhibitor LGK974 (Koo et al, 2012; Jiang et al, 2013).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60353	Frizzled-6	FZD6	view
O75197	Low-density lipoprotein receptor-related protein 5	LR3 LRP5 LRP7	view
O75581	Low-density lipoprotein receptor-related protein 6	LRP6	view
P56704	Protein Wnt-3a	WNT3A	view
Q13467	Frizzled-5	C2orf31 FZD5	view
Q68DV7	E3 ubiquitin-protein ligase RNF43	RNF43	view
Q9H461	Frizzled-8	FZD8	view
Q9ULV1	Frizzled-4	FZD4	view

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