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Phase 4 - resting membrane potential

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5576886

PubChem

R-HSA-5576886

Description

Phase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+ and relatively impermeable to other ions therefore the K+ gradient across the cell membrane is the key determinant in the normal resting potential (Park & Fishman 2011, Grant 2009). In this phase, K+ currents are generated by inward rectifier potassium channels (KCNJs) and tandem pore domain K+ channels (KCNKs). Some Na+/K+-ATPases and Na+/Ca2+-exchangers can also play roles during this phase.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00180	Potassium channel subfamily K member 1	HOHO1 KCNK1 KCNO1 TWIK1	view
O14649	Potassium channel subfamily K member 3	KCNK3 TASK TASK1	view
O95069	Potassium channel subfamily K member 2	KCNK2 TREK TREK1	view
O95279	Potassium channel subfamily K member 5	KCNK5 TASK2	view
P57789	Potassium channel subfamily K member 10	KCNK10 TREK2	view
Q7Z418	Potassium channel subfamily K member 18	KCNK18 TRESK TRIK	view
Q96T54	Potassium channel subfamily K member 17	KCNK17 TALK2 TASK4 UNQ5816/PRO19634	view
Q9HB14	Potassium channel subfamily K member 13	KCNK13	view
Q9HB15	Potassium channel subfamily K member 12	KCNK12	view
Q9NPC2	Potassium channel subfamily K member 9	KCNK9 TASK3	view

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