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TRAF3 deficiency - HSE

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5602571

PubChem

R-HSA-5602571

Description

TNF Receptor Associated Factor 3 (TRAF3) is a cytoplasmic adaptor protein utilized by the tumor necrosis factor receptor superfamily and toll-like receptors (TLRs). TRAF3 deficiency is thought to mimic the previously reported TLR3 deficiency in terms of susceptibility to herpes simplex virus type 1 (HSV1) encephalitis (HSE) via impaired TLR3-mediated immunity against HSV1 infection of central nervous system (CNS) (Pérez de Diego R et al. 2010; Guo Y et al. 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying 1 entry
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15455	Toll-like receptor 3	TLR3	view

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