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Ub-specific processing proteases

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5689880

PubChem

R-HSA-5689880

Description

Ub-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved motifs with N- or C-terminal extensions and insertions occurring between the conserved motifs (Ye et al. 2009). Two highly conserved regions comprise the catalytic triad, the Cys-box (Cys) and His-box (His and Asp/Asn) (Nijman et al. 2005, Ye et al. 2009, Reyes-Turcu & Wilkinson 2009). They recognize their substrates by interactions of the variable regions with the substrate protein directly, or via scaffolds or adapters in multiprotein complexes.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of **100** in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NCW0	Ubiquitin carboxyl-terminal hydrolase 17-like protein 3	USP17B USP17F USP17L3	view
O00231	26S proteasome non-ATPase regulatory subunit 11	PSMD11	view
O00487	Ubiquitin C-terminal hydrolase PSMD14	POH1 PSMD14	view
O14818	Proteasome subunit alpha type-7	HSPC PSMA7	view
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	HGS HRS	view
O15265	Ataxin-7	ATXN7 SCA7	view
O43242	26S proteasome non-ATPase regulatory subunit 3	PSMD3	view
O43303	Centriolar coiled-coil protein of 110 kDa	CCP110 CEP110 CP110 KIAA0419	view
O43318	Mitogen-activated protein kinase kinase kinase 7	MAP3K7 TAK1	view
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view

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