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CD22 mediated BCR regulation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5690714

PubChem

R-HSA-5690714

Description

BCR activation is highly regulated and coreceptors like CD22 (SIGLEC2) set a signalling threshold to prevent aberrant immune response and autoimmune disease (Cyster et al. 1997, Han et al. 2005). CD22 is a glycoprotein found on the surface of B cells during restricted stages of development. CD22 is a member of the receptors of the sialic acid-binding Ig-like lectin (Siglec) family which binds specifically to the terminal sequence N-acetylneuraminic acid alpha(2-6) galactose (NeuAc-alpha(2-6)-Gal) present on many B-cell glycoproteins (Powell et al. 1993, Sgroi et al. 1993). CD22 has seven immunoglobulin (Ig)-like extracellular domains and a cytoplasmic tail containing six tyrosines, three of which belong to the inhibitory immunoreceptor tyrosine-based inhibition motifs (ITIMs) sequences. Upon BCR cross-linking CD22 is rapidly tyrosine phosphorylated by the tyrosine kinase Lyn, thereby recruiting and activating tyrosine phosphatase, SHP-1 and inhibiting calcium signalling.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 14 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01593	Immunoglobulin kappa variable 1D-33	IGKV1D-33	view
P01705	Immunoglobulin lambda variable 2-23	IGLV2-23	view
P01824	Immunoglobulin heavy variable 4-39	IGHV4-39	view
P01834	Immunoglobulin kappa constant	IGKC	view
P01871	Immunoglobulin heavy constant mu	IGHM	view
P01880	Immunoglobulin heavy constant delta	IGHD	view
P04433	Immunoglobulin kappa variable 3-11	IGKV3-11	view
P06315	Immunoglobulin kappa variable 5-2	IGKV5-2	view
P06331	Immunoglobulin heavy variable 4-34	IGHV4-34	view
P0CG04	Immunoglobulin lambda constant 1	IGLC1	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000082	P20273	B-cell receptor CD22	view

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