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Gap-filling DNA repair synthesis and ligation in GG-NER

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5696397

PubChem

R-HSA-5696397

Description

Global genome nucleotide excision repair (GG-NER) is completed by DNA repair synthesis that fills the single stranded gap created after dual incision of the damaged DNA strand and excision of the ~27-30 bases long oligonucleotide that contains the lesion. DNA synthesis is performed by DNA polymerases epsilon or delta, or the Y family DNA polymerase kappa (POLK), which are loaded to the repair site after 5' incision (Staresincic et al. 2009, Ogi et al. 2010). DNA ligases LIG1 or LIG3 ligate the newly synthesized stretch of oligonucleotides to the incised DNA strand (Arakawa et al. 2012, Paul-Konietzko et al. 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P12004	DNA sliding clamp PCNA	PCNA	view
P15927	Replication protein A 32 kDa subunit	REPA2 RPA2 RPA32 RPA34	view
P18858	DNA ligase 1	LIG1	view
P18887	DNA repair protein XRCC1	XRCC1	view
P27694	Replication protein A 70 kDa DNA-binding subunit	REPA1 RPA1 RPA70	view
P28340	DNA polymerase delta catalytic subunit	POLD POLD1	view
P35249	Replication factor C subunit 4	RFC4	view
P35251	Replication factor C subunit 1	RFC1 RFC140	view
P40937	Replication factor C subunit 5	RFC5	view
P49005	DNA polymerase delta subunit 2	POLD2	view

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