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Choline catabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6798163

PubChem

R-HSA-6798163

Description

Choline is an essential water-soluble nutrient in humans, serving as a precursor of phospholipids and the neurotransmitter acetylcholine. It is often associated with B vitamins based on its chemical structure but it isn't an official B vitamin. Its oxidation to betaine provides a link to folate-dependent, one-carbon metabolism where betaine is a methyl donor in the methionine cycle. Betaine is further metabolised to dimethylglycine which is cleared by the kidney (Ueland 2011, Hollenbeck 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P49419	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1 ATQ1	view
Q8IWA5	Choline transporter-like protein 2	CTL2 PSEC0210 SLC44A2	view
Q8WWI5	Choline transporter-like protein 1	CD92 CDW92 CTL1 SLC44A1	view
Q9H015	Solute carrier family 22 member 4	ETT OCTN1 SLC22A4 UT2H	view
Q9UL12	Sarcosine dehydrogenase, mitochondrial	DMGDHL1 SARDH	view

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