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TP53 Regulates Transcription of Caspase Activators and Caspases

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6803207

PubChem

R-HSA-6803207

Description

TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04637	Cellular tumor antigen p53	P53 TP53	view
P55212	Caspase-6	CASP6 MCH2	view
Q13315	Serine-protein kinase ATM	ATM	view
Q9HB75	p53-induced death domain-containing protein 1	LRDD PIDD PIDD1	view

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