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COPI-mediated anterograde transport

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6807878

PubChem

R-HSA-6807878

Description

The ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2005; reviewed in Szul and Sztul, 2011). The ERGIC concentrates COPII-derived cargo from the ER for further anterograde transport to the cis-Golgi and also recycles resident ER proteins back to the ER through retrograde traffic. Both of these pathways appear to make use of microtubule-directed COPI-coated vesicles (Pepperkok et al, 1993; Presley et al, 1997; Scales et al, 1997; Stephens and Pepperkok, 2002; Stephens et al, 2000; reviewed in Lord et al, 2001; Spang et al, 2013).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 61 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
O14576	Cytoplasmic dynein 1 intermediate chain 1	DNCI1 DNCIC1 DYNC1I1	view
O15020	Spectrin beta chain, non-erythrocytic 2	KIAA0302 SCA5 SPTBN2	view
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DNCLI2 DYNC1LI2 LIC2	view
O60763	General vesicular transport factor p115	USO1 VDP	view
P02549	Spectrin alpha chain, erythrocytic 1	SPTA SPTA1	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P08174	Complement decay-accelerating factor	CD55 CR DAF	view
P11277	Spectrin beta chain, erythrocytic	SPTB SPTB1	view
P13987	CD59 glycoprotein	CD59 MIC11 MIN1 MIN2 MIN3 MSK21 hCG_2033390	view

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