GlyCosmos Portal

Submissions

PI5P Regulates TP53 Acetylation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6811555

PubChem

R-HSA-6811555

Description

Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04637	Cellular tumor antigen p53	P53 TP53	view
P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	PI5P4KA PIP4K2A PIP5K2 PIP5K2A	view
P52564	Dual specificity mitogen-activated protein kinase kinase 6	MAP2K6 MEK6 MKK6 PRKMK6 SKK3	view
P78356	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	PIP4K2B PIP5K2B	view
Q09472	Histone acetyltransferase p300	EP300 P300	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.