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Glycerophospholipid catabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-6814848

PubChem

R-HSA-6814848

Description

Reactions grouped in this pathway because of their shared chemistry - the hydrolysis of various phosphatidyl inositols and related phospholipids. They differ, however, in the tissues in which they occur and in their likely physiological roles. The activities of PNPLA6 and GDPD5 annotated here, for example, are especially prominent in kidney cells where the choline they generate plays a role in protecting cells from osmotic stress (Burg et al. 2007). Expression of others may be correlated with specific developmental events (Corda et al. 2013).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q6UWR7	Glycerophosphocholine cholinephosphodiesterase ENPP6	ENPP6 UNQ1889/PRO4334	view
Q6ZV29	Patatin-like phospholipase domain-containing protein 7	C9orf111 PNPLA7	view
Q8IY17	Patatin-like phospholipase domain-containing protein 6	NTE PNPLA6	view
Q8WTR4	Glycerophosphodiester phosphodiesterase domain-containing protein 5	GDE2 GDPD5 PP6037 PP9363 UNQ1850/PRO3580	view
Q9NZC3	Glycerophosphodiester phosphodiesterase 1	GDE1 MIR16	view

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