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Processive synthesis on the lagging strand

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-69183

PubChem

R-HSA-69183

Description

The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P09884	DNA polymerase alpha catalytic subunit	POLA POLA1	view
P12004	DNA sliding clamp PCNA	PCNA	view
P18858	DNA ligase 1	LIG1	view
P28340	DNA polymerase delta catalytic subunit	POLD POLD1	view
P49005	DNA polymerase delta subunit 2	POLD2	view
Q14181	DNA polymerase alpha subunit B	POLA2	view
Q15054	DNA polymerase delta subunit 3	KIAA0039 POLD3	view

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