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Purine catabolism

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-74259

PubChem

R-HSA-74259

Description

The purine bases guanine and hypoxanthine (derived from adenine by events in the purine salvage pathways) are converted to xanthine and then to urate uric acid, which is excreted from the body (Watts 1974). The end-point of this pathway in humans and hominoid primates is unusual. Most other mammals metabolize uric acid further to yield more soluble end products, and much speculation has centered on possible roles for high uric acid levels in normal human physiology.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P21589	5'-nucleotidase	NT5 NT5E NTE	view
Q9Y2T3	Guanine deaminase	GDA KIAA1258	view

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