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Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-77346

PubChem

R-HSA-77346

Description

The fourth pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid decanoyl-CoA and produces octanoyl-CoA. Four enzymatic steps are required starting with MCAD CoA dehydrogenase (Medium Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and completed by the ketoacyl-CoA thiolase activity, present in the mitochondrial membrane associated trifunctional protein. Note that the 3-hydroxyacyl-CoA dehydrogenase activity of SCHAD is not actually limited to short chain fatty acids, in fact SCHAD has a broad substrate specificity.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P11310	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	view
P30084	Enoyl-CoA hydratase, mitochondrial	ECHS1	view
P40939	Trifunctional enzyme subunit alpha, mitochondrial	HADH HADHA	view

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