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Synthesis of PIPs in the nucleus

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8847453

PubChem

R-HSA-8847453

Description

Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase. Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase TMEM55B translocates to the nucleus under stress via an unknown mechanism (Zou et al. 2007) and generates PI5P from the PI(4,5)P2 substrate. The level of PI5P in the nucleus is kept low because of the phosphatidylinositol-5-phosphate 4-kinase activity of nuclear PIP4K2 dimers, mainly dimers containing PIP4K2B (Ciruela et al. 2000). Under conditions of cellular stress, nuclear PIP4K2B is phosphorylated and inactivated by p38 MAP family kinases (Jones et al. 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P48426	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	PI5P4KA PIP4K2A PIP5K2 PIP5K2A	view
P78356	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	PIP4K2B PIP5K2B	view

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