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MET activates PTPN11

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8865999

PubChem

R-HSA-8865999

Description

PTPN11 (SHP2), recruited to activated MET receptor through GAB1, is phosphorylated in response to HGF treatment, although phosphorylation sites and direct MET involvement have not been examined (Schaeper et al. 2000, Duan et al. 2006). Phosphorylation of PTPN11 in response to HGF treatment is required for the recruitment and activation of sphingosine kinase SPHK1, which may play a role in HGF-induced cell scattering (Duan et al. 2006). While PTPN11 promotes MAPK3/1 (ERK1/2) signaling downstream of MET, it can also dephosphorylate MET on unidentified tyrosine residues (Furcht et al. 2014).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08581	Hepatocyte growth factor receptor	MET	view
P14210	Hepatocyte growth factor	HGF HPTA	view
Q06124	Tyrosine-protein phosphatase non-receptor type 11	PTP2C PTPN11 SHPTP2	view
Q13480	GRB2-associated-binding protein 1	GAB1	view

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