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InlB-mediated entry of Listeria monocytogenes into host cell

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8875360

PubChem

R-HSA-8875360

Description

InlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist (Shen et al. 2000, Veiga and Cossart 2005). Listeria monocytogenes InlB proteins dimerize through their leucine-rich repeat regions (LRRs), promoting dimerization of MET receptors that they are bound to (Ferraris et al. 2010). InlB-induced MET receptor dimerization is followed by MET trans-autophosphorylation and activation of downstream RAS/RAF/MAPK signaling and PI3K/AKT signaling (Niemann et al. 2007, Ferraris et al. 2010). InlB-bound phosphorylated MET receptor recruits the E3 ubiquitin ligase CBL through GRB2. CBL-mediated monoubiquitination of InlB-bound MET promotes endocytosis and entry of Listeria monocytogenes to host cells (Veiga and Cossart 2005). CIN85 is necessary for endocytosis-mediated entry of Listeria monocytogenes triggered by CBL-mediated monoubiquitination of MET (Veiga and Cossart 2005). Proteins involved in clathrin-mediated endocytosis EPS15 and HGS (Hrs) are both necessary for CBL and MET-mediated entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
A potential coreceptor role of CD44 in InlB-mediated MET activation is contradictory (Jung et al. 2009, Dortet et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	HGS HRS	view
O75886	Signal transducing adapter molecule 2	HBP STAM2	view
P08581	Hepatocyte growth factor receptor	MET	view
P22681	E3 ubiquitin-protein ligase CBL	CBL CBL2 RNF55	view
P42566	Epidermal growth factor receptor substrate 15	AF1P EPS15	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
Q96B97	SH3 domain-containing kinase-binding protein 1	CIN85 SH3KBP1	view
Q99961	Endophilin-A2	CNSA1 SH3D2B SH3GL1	view
Q99963	Endophilin-A3	CNSA3 SH3D2C SH3GL3	view

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