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MET activates RAP1 and RAC1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8875555

PubChem

R-HSA-8875555

Description

The adapter protein GAB1 is involved in recruitment, through CRK and related CRKL proteins, of guanyl nucleotide exchange factors (GEFs) to the activated MET receptor. MET-associated GEFs, such as RAPGEF1 (C3G) and DOCK7, activate RAP1 and RAC1, respectively, leading to morphological changes that contribute to cell motility (Schaeper et al. 2000, Sakkab et al. 2000, Lamorte et al. 2002, Watanabe et al. 2006, Murray et al. 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08581	Hepatocyte growth factor receptor	MET	view
P14210	Hepatocyte growth factor	HGF HPTA	view
P46108	Adapter molecule crk	CRK	view
P46109	Crk-like protein	CRKL	view
P63000	Ras-related C3 botulinum toxin substrate 1	MIG5 RAC1 TC25	view
Q13480	GRB2-associated-binding protein 1	GAB1	view
Q96N67	Dedicator of cytokinesis protein 7	DOCK7 KIAA1771	view

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