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MET receptor recycling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8875656

PubChem

R-HSA-8875656

Description

Activated MET receptor is subject to recycling from the plasma membrane through the endosomal compartment and back to the plasma membrane (Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). In the recycling process, activated MET receptor is endocytosed, and the GGA3 protein directs it, via a largely unknown mechanism, through the RAB4 positive endosomal compartments back to the plasma membrane (Parachoniak et al. 2011). Endosomal signaling by MET during the recycling process appears to play an important role in sustained activation of ERK1/ERK2 (MAPK3/MAPK1) and STAT3 downstream of MET (Kermorgant and Parker 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08581	Hepatocyte growth factor receptor	MET	view
P14210	Hepatocyte growth factor	HGF HPTA	view
P46108	Adapter molecule crk	CRK	view
P46109	Crk-like protein	CRKL	view
Q13480	GRB2-associated-binding protein 1	GAB1	view
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	GGA3 KIAA0154	view

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