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RUNX1 regulates estrogen receptor mediated transcription

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8931987

PubChem

R-HSA-8931987

Description

The RUNX1:CBFB complex can associate with the activated estrogen receptor alpha (ESR1) through direct interaction between RUNX1 and ESR1. The RUNX1:CBFB complex is thus involved in transcriptional regulation of estrogen responsive genes, including GPAM, KCTD6 and AXIN1 (Stender et al. 2010). High GPAM expression correlates with better overall survival in breast cancer (Brockmoller et al. 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P03372	Estrogen receptor	ESR ESR1 NR3A1	view
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view
Q13951	Core-binding factor subunit beta	CBFB	view
Q9HCL2	Glycerol-3-phosphate acyltransferase 1, mitochondrial	GPAM GPAT1 KIAA1560	view

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