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RUNX1 regulates expression of components of tight junctions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8935964

PubChem

R-HSA-8935964

Description

The RUNX1 transcription factor, which functions as part of the RUNX1:CBFB complex, was shown to directly transcriptionally regulate expression of several genes that encode components of tight junctions. Namely, RUNX1 binds to promoters of TJP1 (encoding ZO-1), OCLDN (encoding Occludin) and CLDN5 (encoding Claudin-5) and stimulates their transcription. Downregulation of RUNX1 by microRNA miR-18a negatively regulates expression of these three tight junction genes, which may affect the permeability of blood-tumor barrier in glioma (Miao et al. 2015).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view
Q07157	Tight junction protein 1	TJP1 ZO1	view
Q13951	Core-binding factor subunit beta	CBFB	view
Q16625	Occludin	OCLN	view

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