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RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8939242

PubChem

R-HSA-8939242

Description

The RUNX1:CBFB complex directly inhibits transcription of the SERPINB13 gene (Nomura et al. 2005), a gene involved in keratinocyte differentiation that is frequently down-regulated in head and neck cancers (Boyapati et al. 2011). RUNX1 also inhibits transcription of STAT3 inhibitors SOCS3 and SOCS4, resulting in elevated STAT3 activity. RUNX1-mediated increase in STAT3 activity, first discovered in keratinocytes, is thought to be involved in the maintenance of epithelial stem cells and contributes to development of epithelial cancers, including squamous cell carcinoma (SCC) of the skin (Scheitz et al. 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14543	Suppressor of cytokine signaling 3	CIS3 SOCS3 SSI3	view
O60911	Cathepsin L2	CATL2 CTSL2 CTSU CTSV UNQ268/PRO305	view
P07711	Procathepsin L	CTSL CTSL1 hCG_30369	view
P43235	Cathepsin K	CTSK CTSO CTSO2	view
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view
Q13951	Core-binding factor subunit beta	CBFB	view

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