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RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8939243

PubChem

R-HSA-8939243

Description

The transcriptional activity of the RUNX1:CBFB complex is regulated by interaction with co-factors and posttranslational modifications of RUNX1. Protein serine/threonine kinase HIPK2 can phosphorylate RUNX1 and affect transcriptional activity of the RUNX1:CBFB complex during hematopoiesis. Some CBFB mutations found in leukemia interfere with HIPK2-mediated phosphorylation of RUNX1. HIPK2 can simultaneously phosphorylate RUNX1 and EP300 (p300) bound to the RUNX1:CBFB1 complex (Aikawa et al. 2006, Wee et al. 2008).
The RUNX1:CBFB complex can associate with the polycomb repressor complex 1 (PRC1). PRC1 complexes are found at many RUNX1 target promoters and can act either as co-activators or co-repressors in the transactivation of RUNX1 targets (Yu et al. 2011).
RUNX1 recruits the SWI/SNF chromatin remodeling complex to many RUNX1 target promoters by directly interacting with several SWI/SNF subunits (Bakshi et al. 2010).
Other co-factors of the RUNX1:CBFB complex are annotated in the context of transcriptional regulation of specific genes.

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 30 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00257	E3 SUMO-protein ligase CBX4	CBX4	view
O14497	AT-rich interactive domain-containing protein 1A	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	view
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P19784	Casein kinase II subunit alpha'	CK2A2 CSNK2A2	view
P35226	Polycomb complex protein BMI-1	BMI1 PCGF4 RNF51	view
P51531	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	BAF190B BRM SMARCA2 SNF2A SNF2L2	view
P51532	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4	BAF190A BRG1 SMARCA4 SNF2B SNF2L4	view
P68400	Casein kinase II subunit alpha	CK2A1 CSNK2A1	view
P78364	Polyhomeotic-like protein 1	EDR1 PH1 PHC1	view
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view

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