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RUNX1 regulates transcription of genes involved in BCR signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8939245

PubChem

R-HSA-8939245

Description

The RUNX1:CBFB complex, in association with transcription co-factors ELF1 (MEF), ELF2 (NERF2) or PAX5 (BSAP) stimulates transcription of the BLK gene, encoding a B-cell specific tyrosine kinase involved in B cell receptor (BCR) signaling, B cell development and differentiation (Libermann et al. 1999, Cho et al. 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P32519	ETS-related transcription factor Elf-1	ELF1	view
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view
Q13951	Core-binding factor subunit beta	CBFB	view
Q15723	ETS-related transcription factor Elf-2	ELF2 NERF	view

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