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RUNX1 regulates transcription of genes involved in WNT signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8939256

PubChem

R-HSA-8939256

Description

The RUNX1:CBFB complex directly regulates transcription of at least two components of WNT signaling. In association with its co-factor FOXP3, the RUNX1:CBFB complex stimulates transcription of the RSPO3 gene, encoding a WNT ligand that is implicated as a breast cancer oncogene (Recouvreux et al. 2016). In association with the activated estrogen receptor alpha (ESR1), the RUNX1:CBFB complex stimulates the expression of AXIN1, which functions as a regulator of WNT signaling (Stender et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P03372	Estrogen receptor	ESR ESR1 NR3A1	view
Q01196	Runt-related transcription factor 1	AML1 CBFA2 RUNX1	view
Q13951	Core-binding factor subunit beta	CBFB	view
Q9BXY4	R-spondin-3	PWTSR RSPO3 THSD2	view

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