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Invadopodia formation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8941237

PubChem

R-HSA-8941237

Description

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to and degradation of the extracellular matrix (Linder & Kopp 2005, Murphy & Courtneidge 2011). They are characteristically composed of an actin-rich core surrounded by adhesion and scaffolding proteins. Current convention is to use the term podosome for the structures found in normal cells (such as monocytic cells, endothelial cells and smooth muscle cells) and in Src-transformed fibroblasts, and invadopodium for the structures found in cancer cells. The maturation process for podosomes and invadopodia involves the recruitment and activation of multiple pericellular proteases, which facilitates ECM degradation (Artym et al. 2006).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43184	Disintegrin and metalloproteinase domain-containing protein 12	ADAM12 MLTN UNQ346/PRO545	view
Q13444	Disintegrin and metalloproteinase domain-containing protein 15	ADAM15 MDC15	view
Q5TCZ1	SH3 and PX domain-containing protein 2A	FISH KIAA0418 SH3MD1 SH3PXD2A TKS5	view
Q9H013	Disintegrin and metalloproteinase domain-containing protein 19	ADAM19 FKSG34 MLTNB	view

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