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RUNX3 regulates CDKN1A transcription

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8941855

PubChem

R-HSA-8941855

Description

RUNX3 contributes to the upregulation of the CDKN1A (p21) gene transcription in response to TGF-beta (TGFB1) signaling. RUNX3 binds to SMAD3 and SMAD4, and cooperates with the activated SMAD3:SMAD4 complex in transactivation of CDKN1A. Runx3 knockout mice exhibit decreased sensitivity to TGF-beta and develop gastric epithelial hyperplasia (Chi et al. 2005). In response to TGF-beta signaling, the CBFB:RUNX3 complex binds to the tumor suppressor ZFHX3 (ATBF1) and, through an unknown mechanism, this complex positively regulates the CDKN1A transcription (Mabuchi et al. 2010).
In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01137	Transforming growth factor beta-1 proprotein	TGFB TGFB1	view
P04637	Cellular tumor antigen p53	P53 TP53	view
Q13485	SMAD family member 4	DPC4 MADH4 SMAD4	view
Q13761	Runt-related transcription factor 3	AML2 CBFA3 PEBP2A3 RUNX3	view
Q15911	Zinc finger homeobox protein 3	ATBF1 C16orf47 ZFHX3	view

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