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Cristae formation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8949613

PubChem

R-HSA-8949613

Description

Cristae are invaginations of the inner mitochondrial membrane that extend into the matrix and are lined with cytochrome complexes and F1Fo ATP synthase complexes. Cristae increase the surface area of the inner membranes allowing greater numbers of respiratory complexes. Cristae are also believed to serve as "proton pockets" to generate localized regions of higher membrane potential. The steps in the biogenesis of cristae are not yet completely elucidated (reviewed in Zick et al. 2009) but the formation of the Mitochondrial Contact Site and Cristae Organizing System (MICOS, formerly also known as MINOS, reviewed in Rampelt et al. 2016, Kozjak-Pavlovic 2016, van der Laan et al. 2016) and localized concentrations of cardiolipin are known to define the inward curvature of the inner membrane at the bases of cristae. MICOS also links these regions of the inner membrane with complexes (the SAM complex and, in fungi, the TOM complex) embedded in the outer membrane. CHCHD3 (MIC19) and IMMT (MIC60) subunits of MICOS also interact with OPA1 at the inner membrane (Darshi et al. 2011, Glytsou et al. 2016).
Formation of dimers or oligomers of the F1Fo ATP synthase complex causes extreme curvature of the inner membrane at the apices of cristae (reviewed in Seelert and Dencher 2011, Habersetzer et al. 2013). Defects in either MICOS or F1Fo ATP synthase oligomerization produce abnormal mitochondrial morphologies.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P06576	ATP synthase F(1) complex subunit beta, mitochondrial	ATP5B ATP5F1B ATPMB ATPSB	view
P25705	ATP synthase F(1) complex subunit alpha, mitochondrial	ATP5A ATP5A1 ATP5AL2 ATP5F1A ATPM	view
P36542	ATP synthase F(1) complex subunit gamma, mitochondrial	ATP5C ATP5C1 ATP5CL1 ATP5F1C	view
P38646	Stress-70 protein, mitochondrial	GRP75 HSPA9 HSPA9B mt-HSP70	view
P56385	ATP synthase F(0) complex subunit e, mitochondrial	ATP5I ATP5K ATP5ME	view
Q16891	MICOS complex subunit MIC60	HMP IMMT MIC60 MINOS2 PIG4 PIG52	view
Q9BRQ6	MICOS complex subunit MIC25	CHCHD6 CHCM1 MIC25	view
Q9BUR5	MICOS complex subunit MIC26	APOO FAM121B MIC23 MIC26 My025 UNQ1866/PRO4302	view
Q9NVH1	DnaJ homolog subfamily C member 11	DNAJC11	view
Q9NX63	MICOS complex subunit MIC19	CHCHD3 MIC19 MINOS3	view

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