GlyCosmos Portal

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Intestinal hexose absorption

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8981373

PubChem

R-HSA-8981373

Description

Hexoses, notably fructose, glucose, and galactose generated in the lumen of the small intestine by breakdown of dietary carbohydrate, are taken up by enterocytes lining the microvilli of the small intestine and released from them into the blood. Uptake into enterocytes is mediated by two transporters localized on the luminal surfaces of the cells. SLC5A1, also known as SGLT1, mediates the co-transport of sodium ions and glucose and galactose, and SLC2A5, also known as GLUT5, mediates fructose uptake (Wright 1998). Tetrameric SLC2A2, also known as GLUT2, localized on the basolateral surfaces of enterocytes, mediates the release of these hexoses into the blood (Kellett & Brot-Laroche 2005; Wright et al. 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P11168	Solute carrier family 2, facilitated glucose transporter member 2	GLUT2 SLC2A2	view
P13866	Sodium/glucose cotransporter 1	NAGT SGLT1 SLC5A1	view
P22732	Solute carrier family 2, facilitated glucose transporter member 5	GLUT5 SLC2A5	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_004531	P22732	Solute carrier family 2, facilitated glucose transporter member 5	view

Displaying **all 2** entries
GlyTouCan ID	KEGG GLYCAN	ChEBI	Pathway Viewer
G15021LG	G12504	4167	view
G93924TT		17118	view

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