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CDC42 GTPase cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9013148

PubChem

R-HSA-9013148

Description

This pathway catalogues CDC42 guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and CDC42 effectors. CDC42 is one of the three best characterized RHO GTPases, the other two being RHOA and RAC1. By regulating the cytoskeleton, CDC42 regulates cell polarity across different species, from yeast to humans (Pichaud et al. 2019, Woods and Lew 2019). CDC42 is an essential regulator of polarized morphogenesis in epithelial cells, where it coordinates formation of the apical membrane and lumen formation, as well as junction maturation (Pichaud et al. 2019). CDC42 plays a role in cell-to-cell adhesion and cell cycle regulation (Xiao et al. 2018). CDC42 takes part in the regulation of membrane trafficking. Dysfunction of several CDC42-specific GEFs has been shown to impair intracellular trafficking (Egorov and Polishchuk 2017). CDC42 participates in insulin synthesis and secretion and contributes to the pathogenesis of insulin resistance and diabetic nephropathy (Huang et al. 2019). CDC42 is often dysregulated in cancer because a number of GEFs and GEF activators that act upstream of RAC1 and CDC42 are known oncogenes (Aguilar et al. 2017; Maldonado et al. 2018; Zhang et al. 2019; Maldonado et al. 2020). CDC4 promotes cancer cell proliferation, survival, invasion, migration and metastasis (Xiao et al. 2018), especially under hyperglycemia (Huang et al. 2019).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 99 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NGB9	WAS/WASL-interacting protein family member 3	CR16 WIPF3	view
A7KAX9	Rho GTPase-activating protein 32	ARHGAP32 GRIT KIAA0712 RICS	view
O00161	Synaptosomal-associated protein 23	SNAP23	view
O00401	Actin nucleation-promoting factor WASL	WASL	view
O14559	Rho GTPase-activating protein 33	ARHGAP33 SNX26 TCGAP	view
O14827	Ras-specific guanine nucleotide-releasing factor 2	GRF2 RASGRF2	view
O15085	Rho guanine nucleotide exchange factor 11	ARHGEF11 KIAA0380	view
O43295	SLIT-ROBO Rho GTPase-activating protein 3	ARHGAP14 KIAA0411 KIAA1156 MEGAP SRGAP2 SRGAP3	view
O43516	WAS/WASL-interacting protein family member 1	WASPIP WIP WIPF1	view
O60890	Oligophrenin-1	OPHN1	view

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