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Noncanonical activation of NOTCH3

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9017802

PubChem

R-HSA-9017802

Description

Besides DLL/JAG ligands, NOTCH3 signaling can also be activated by binding of NOTCH3 to YBX1 (YB 1) (Rauen et al. 2009). YBX1, a protein involved in mRNA processing, is secreted by mesangial cells and monocytes during inflammation and acts as an extracellular mitogen (Frye et al. 2009). YBX1 triggers the gamma secretase complex mediated cleavage of NOTCH3, resulting in release of NOTCH3 intracellular domain (NICD3) and activation of NOTCH3 target genes (Rauen et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P67809	Y-box-binding protein 1	NSEP1 YB1 YBX1	view
Q92542	Nicastrin	KIAA0253 NCSTN UNQ1874/PRO4317	view
Q96BI3	Gamma-secretase subunit APH-1A	APH1A CGI-78 PSF UNQ579/PRO1141	view
Q9UM47	Neurogenic locus notch homolog protein 3	NOTCH3	view

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