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NTF3 activates NTRK2 (TRKB) signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9025046

PubChem

R-HSA-9025046

Description

Neurotrophin receptor tyrosine kinase NTRK2 (TRKB) is a low affinity receptor for neurotrophin-3 (NTF3, also known as NT-3) (Soppet et al. 1991). NTF3 predominantly functions as the ligand for the NTRK3 (TRKC) receptor (Marsh and Palfrey 1996). Binding to NTF3 can trigger NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Middlemas et al. 1994). The efficacy of this process, however, is low in comparison to NTRK2 activation by BDNF and NTF3, and downstream signaling has not been studied.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P20783	Neurotrophin-3	NTF3	view
Q16620	BDNF/NT-3 growth factors receptor	NTRK2 TRKB	view

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