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Activated NTRK2 signals through RAS

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9026519

PubChem

R-HSA-9026519

Description

Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P01111	GTPase NRas	HRAS1 NRAS	view
P01112	GTPase HRas	HRAS HRAS1	view
P23560	Neurotrophic factor BDNF precursor form	BDNF	view
P34130	Neurotrophin-4	NTF4 NTF5	view
Q07889	Son of sevenless homolog 1	SOS1	view
Q16620	BDNF/NT-3 growth factors receptor	NTRK2 TRKB	view

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