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Activated NTRK3 signals through PI3K

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9603381

PubChem

R-HSA-9603381

Description

The PI3K complex, composed of PIK3R1 and PIK3CA, co-immunoprecipitates with NTRK3 (TRKC), activated by NTF3 (NT-3) treatment (Yuen and Mobley 1999). Activation of NTRK3 correlates with activating phosphorylation of AKT, the main mediator of PI3K signaling (Tognon et al. 2001, Jin et al. 2008), and is dependent on PI3K activity (Tognon et al. 2001). NTRK3-mediated activation of PI3K signaling depends on SRC activation and the adaptor protein IRS1, but the exact mechanism is not known (Morrison et al. 2002, Lannon et al. 2004, Jin et al. 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P12931	Proto-oncogene tyrosine-protein kinase Src	SRC SRC1	view
P20783	Neurotrophin-3	NTF3	view
P35568	Insulin receptor substrate 1	IRS1	view
Q16288	NT-3 growth factor receptor	NTRK3 TRKC	view

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