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GPER1 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9634597

PubChem

R-HSA-9634597

Description

GPER1 (also known as GPR30) is an orphan G-protein coupled receptor that has been suggested to act as an alternate estrogen receptor (Revankar et al, 2005; Filardo et al, 2007; reviewed in Prossnitz and Barton, 2011; Gaudet et al, 2015). In support of this, a number of studies have shown that GPER1 stimulates MAPK and cAMP activation in response to estrogen in ESR1 negative breast cancer cells. Similar to classical ESR1-mediated signaling, this estrogen-responsive GPER1 is suggested to act through G beta gamma and to involve EGFR transactivation (Filardo et al, 2000; Filardo et al, 2002; reviewed in Filardo and Thomas, 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 24 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8MTJ3	Guanine nucleotide-binding protein G(t) subunit alpha-3	GNAT3	view
O43306	Adenylate cyclase type 6	ADCY6 KIAA0422	view
O60266	Adenylate cyclase type 3	ADCY3 KIAA0511	view
O60503	Adenylate cyclase type 9	ADCY9 KIAA0520	view
O95622	Adenylate cyclase type 5	ADCY5	view
P02751	Fibronectin	FN FN1	view
P04899	Guanine nucleotide-binding protein G(i) subunit alpha-2	GNAI2 GNAI2B	view
P05556	Integrin beta-1	FNRB ITGB1 MDF2 MSK12	view
P08648	Integrin alpha-5	FNRA ITGA5	view
P08754	Guanine nucleotide-binding protein G(i) subunit alpha-3	GNAI3	view

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