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Aggrephagy

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9646399

PubChem

R-HSA-9646399

Description

When the capacity of the proteosome to degrade misfolded proteins is limited, the alternate route to eliminate denatured proteins is via forming aggresomes - a process known as aggrephagy. Aggresome formation starts with ubiquitination of misfolded proteins following transport to the microtubule-organizing center (MTOC) with the help of dynein motor proteins. At the MTOC the cargo is encapsulated with intermediate filament proteins to result in the aggresome. Subsequently, this aggresome recruits chaperones that result in its autophagic elimination (Garcia Mata R et al. 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 27 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
O14576	Cytoplasmic dynein 1 intermediate chain 1	DNCI1 DNCIC1 DYNC1I1	view
O43237	Cytoplasmic dynein 1 light intermediate chain 2	DNCLI2 DYNC1LI2 LIC2	view
O95613	Pericentrin	KIAA0402 PCNT PCNT2	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P08670	Vimentin	VIM	view
P13569	Cystic fibrosis transmembrane conductance regulator	ABCC7 CFTR	view
P55072	Transitional endoplasmic reticulum ATPase	HEL-220 HEL-S-70 VCP	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view

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