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Drug-mediated inhibition of ERBB2 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9652282

PubChem

R-HSA-9652282

Description

Signaling by ERBB2 can be pharmacologically inhibited with tyrosine kinase inhibitors (TKIs) (Nelson and Fry 2001, Xia et al. 2002, Wood et al. 2004, Rabindran et al. 2004, Gandreau et al. 2007, Jani et al. 2007, Li et al. 2008, Hichkinson et al. 2010, Traxler et al. 2014, Hanker et al. 2017), and therapeutic antibodies, such as trastuzumab (Hudziak et al. 1989, Carter et al. 1992, Pickl and Ries 2009, Maadi et al. 2018) and pertuzumab (Franklin et al. 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04626	Receptor tyrosine-protein kinase erbB-2	ERBB2 HER2 MLN19 NEU NGL	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
Q16543	Hsp90 co-chaperone Cdc37	CDC37 CDC37A	view
Q96RT1	Erbin	ERBB2IP ERBIN KIAA1225 LAP2	view

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