GlyCosmos Portal

Submissions

Drug resistance in ERBB2 TMD/JMD mutants

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9665737

PubChem

R-HSA-9665737

Description

With respect to pertuzumab, a therapeutic antibody that block ligand-driven heterodimerization of ERBB2, ERBB2 R678Q is sensitive to pertuzumab, while ERBB2 V659E, ERBB2 G660D, ERBB2 G660R and probably ERBB2 Q709L are resistant (Pahuja et al. 2018).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04626	Receptor tyrosine-protein kinase erbB-2	ERBB2 HER2 MLN19 NEU NGL	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
Q16543	Hsp90 co-chaperone Cdc37	CDC37 CDC37A	view
Q96RT1	Erbin	ERBB2IP ERBIN KIAA1225 LAP2	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.