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Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9670613

PubChem

R-HSA-9670613

Description

A small portion of tumors that are positive for alternative lengthening of telomeres (ALT) markers and negative for mutations in the ATRX gene harbor loss-of-function mutations in the DAXX gene, which encodes the ATRX binding partner DAXX. For review, please refer to Gocha et al. 2013, and Pickett and Reddel 2015.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P46100	Transcriptional regulator ATRX	ATRX RAD54L XH2	view
Q9UER7	Death domain-associated protein 6	BING2 DAP6 DAXX	view

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