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Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9670615

PubChem

R-HSA-9670615

Description

Many tumors that are positive for markers of alternative lengthening of telomeres (ALT) harbor loss-of-function mutations in the ATRX gene, encoding a chromatin remodeling protein ATRX. ATRX is thought to act together with DAXX and histone H3F3A to inhibit DNA recombination at telomere ends. For review, please refer to Heaphy et al. 2011, Gocha et al. 2014, Pickett and Reddel 2015, Amorim et al. 2016.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 2** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P46100	Transcriptional regulator ATRX	ATRX RAD54L XH2	view
Q9UER7	Death domain-associated protein 6	BING2 DAP6 DAXX	view

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