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Translation of Structural Proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9683701

PubChem

R-HSA-9683701

Description

SARS-CoV-1 mRNA is translated according to the ribosomal scanning model. Virus mRNA is capped and polyadenylated, with regions of nontranslated sequences on both the 5' and 3' ends. Structural proteins are encoded after the polymerase/replicase genes by mRNAs 2 (Spike protein), 3, 4 (Envelope protein), 5 (Membrane protein), and 9. mRNA 3 and 9 are bicistronic, the proteins 3a and 9a (Nucleocapsid protein) having functions in virus assembly and structure. Translation happens in the ER with the exception of 9a which is translated by cytosolic free ribosomes (Fung and Liu, 2019).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 3** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P59594	Spike glycoprotein	2 S	view
P59596	Membrane protein	5 M	view
P59632	ORF3a protein	3a	view

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