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SARS-CoV-1 targets PDZ proteins in cell-cell junction

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9692912

PubChem

R-HSA-9692912

Description

PDZ domains are protein‑protein recognition sequences, consisting of 80–90 amino acids that bind to a PDZ‑binding motif (PBM), usually located at the carboxy‑terminus of a target protein (Hung AY & Sheng M 2002; Gerek ZN et al. 2009; Munz M et al. 2012). Proteins containing PDZ domains are typically found in the cell cytoplasm or in association with the plasma membrane and play a role in cell‑cell junction formation, establishment of cellular polarity, and signal transduction pathways. The multidomain structure of PDZ-containing proteins enables them to interact with multiple binding partners simultaneously, thereby assembling larger protein complexes (Harris BZ & Lim WA 2001). Viruses also encode PBM-containing proteins that bind to cellular PDZ proteins. Viral PBMs target cellular PDZ-containing proteins involved in tight junction formation, cell polarity establishment, and apoptosis (Javier RT & Rice AP 2011).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying 1 entry
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
Q8N3R9	Protein PALS1	MPP5 PALS1	view

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