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Inactivation of CSF3 (G-CSF) signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9705462

PubChem

R-HSA-9705462

Description

Signaling by CSF3 causes its own inactivation, thereby preventing overproliferation of neutrophils (reviewed in Beekman and Touw 2010, Palande et al. 2013). Activated CSF3R recruits and activates JAK2, which phosphorylates STAT1, STAT3, and STAT5. The phosphorylated STATs transit to the nucleus and enhance the expression of SOCS1 and SOCS3, inhibitors of CSF3R signaling (inferred from mouse homologs). SOCS3, the principle negative regulator, binds the phosphorylated C-terminal region of CSF3R (Hörtner et al. 2002, van de Geijn et al. 2004, and inferred from mouse homologs) and acts in two ways: direct inhibition of the phosphorylation activity of JAK2 (van de Geijn et al. 2004) and promotion of endocytosis (Ward et al. 1999, Aarts et al. 2004, Irandoust et al. 2007) and ubiquitination (Irandoust et al. 2007, Wölfler et al. 2009) of CSF3R.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 16 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14543	Suppressor of cytokine signaling 3	CIS3 SOCS3 SSI3	view
P08631	Tyrosine-protein kinase HCK	HCK	view
P09919	Granulocyte colony-stimulating factor	C17orf33 CSF3 GCSF	view
P23458	Tyrosine-protein kinase JAK1	JAK1 JAK1A JAK1B	view
P29597	Non-receptor tyrosine-protein kinase TYK2	TYK2	view
P40763	Signal transducer and activator of transcription 3	APRF STAT3	view
P42224	Signal transducer and activator of transcription 1-alpha/beta	STAT1	view
P42229	Signal transducer and activator of transcription 5A	STAT5 STAT5A	view
P43405	Tyrosine-protein kinase SYK	SYK	view
P51692	Signal transducer and activator of transcription 5B	STAT5B	view

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