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FLT3 signaling by CBL mutants

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9706377

PubChem

R-HSA-9706377

Description

Missense and splicing mutants have been identified in the E3 ubiquitin ligase CBL in a number of cancers including acute and chronic myeloid leukemias, among others. These cancers show elevated signaling through FLT3 as a result of impaired CBL-mediated downregulation of the receptor (Sargin et al, 2007; Reindl et al, 2009; Caligiuri et al, 2007; Abbas et al, 2008).

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SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P22681	E3 ubiquitin-protein ligase CBL	CBL CBL2 RNF55	view
P36888	Receptor-type tyrosine-protein kinase FLT3	CD135 FLK2 FLT3 STK1	view
P49771	Fms-related tyrosine kinase 3 ligand	FLT3LG	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view

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