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GABA receptor activation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-977443

PubChem

R-HSA-977443

Description

Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 16 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A8MPY1	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	view
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABRA1	view
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABRB1	view
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	view
P24046	Gamma-aminobutyric acid receptor subunit rho-1	GABRR1	view
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	view
P28476	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	view
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABRA5	view
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABRA3	view
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	view

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