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Regulation of MITF-M-dependent genes involved in pigmentation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9824585

PubChem

R-HSA-9824585

Description

Genes involved in pigmentation and melanocyte structure and organization were among the first identified targets of MITF. Expression of enzymes TYR, DCT and TYRP1, which work sequentially to eventually convert tyrosine into eumelanin and pheomelanin, is regulated in part by the binding of MITF to M-boxes in the promoters (Bentley et al, 1994; Bertolotto et al, 1998; Yavuzer et al, 1995; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). MITF additionally regulates the expression of structural components of the melanosome such as MLANA, SLC24A5, SILV and GPR143, although direct binding and regulation has not been demonstrated in all cases (Du et al, 2003; Cortese et al, 2005; Schiaffino and Tacchetti, 2005; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). Genes encoding RAB27A and MYO5A, which regulate the localization and trafficking of melanosomes, are also targets of MITF (Chiaverini et al, 2008; Alves et al, 2017; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 28 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14497	AT-rich interactive domain-containing protein 1A	ARID1A BAF250 BAF250A C1orf4 OSA1 SMARCF1	view
O75177	Calcium-responsive transactivator	CREST KIAA0693 SS18L1	view
O96019	Actin-like protein 6A	ACTL6A BAF53 BAF53A INO80K	view
P05549	Transcription factor AP-2-alpha	AP2TF TFAP2 TFAP2A	view
P14679	Tyrosinase	TYR	view
P17643	5,6-dihydroxyindole-2-carboxylic acid oxidase	CAS2 TYRP TYRP1 TYRRP	view
P31751	RAC-beta serine/threonine-protein kinase	AKT2	view
P35222	Catenin beta-1	CTNNB CTNNB1 OK/SW-cl.35 PRO2286	view
P40126	L-dopachrome tautomerase	DCT TYRP2	view
P40967	Melanocyte protein PMEL	D12S53E PMEL PMEL17 SILV	view

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