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Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9857377

PubChem

R-HSA-9857377

Description

MITF regulates biogenesis of organelles such as the lysosome and endosomes through its regulation of components of the V-ATPase that is required for organelle acidification and function (Zhang et al, 2015; Ploper et al, 2015a; reviewed in Ploper et al, 2015b). MITF-dependent targets also contribute to autophagy when cells are stressed for nutrients (Möller et al, 2019). MITF additionally controls expression of the lysosome-resident acid ceramidase ASAH1 that has roles in sphingolipid metabolism and cellular proliferation in melanoma (Leclerc et al, 2019; Realini et al, 2016).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15342	V-type proton ATPase subunit e 1	ATP6H ATP6V0E ATP6V0E1	view
P27449	V-type proton ATPase 16 kDa proteolipid subunit c	ATP6C ATP6L ATP6V0C ATPL	view
P36543	V-type proton ATPase subunit E 1	ATP6E ATP6E2 ATP6V1E1	view
P38606	V-type proton ATPase catalytic subunit A	ATP6A1 ATP6V1A ATP6V1A1 VPP2	view
Q13510	Acid ceramidase	ASAH ASAH1 HSD-33 HSD33	view

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